Nilevar

Nilevat

(Norethandrolone)

Nilevar, with the chemical name Norethandrolone, holds a notable place in the history of anabolic steroids. It represents a pioneering advancement in the field of synthetic androgens and anabolic steroids. Here’s a brief overview of its history:

Discovery and Development

  • Introduction: Nilevar was introduced in the 1950s. It is credited as one of the first oral anabolic steroids to be developed and marketed for medical use. Its development was part of the broader effort during the mid-20th century to synthesize derivatives of testosterone that could be used to treat various conditions with fewer androgenic side effects.
  • Chemical Background: Norethandrolone is a synthetic, orally active anabolic-androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone). The addition of the ethyl group at the 17th carbon position allows it to be taken orally, a significant advancement over earlier steroids that required intramuscular injections.

Medical Use

  • Therapeutic Applications: Initially, Nilevar was used for medical purposes. It was prescribed for conditions like chronic wasting diseases, severe burn injuries, osteoporosis, and certain types of anemia. Its anabolic properties were sought to promote muscle growth, appetite, and red blood cell production.
  • Decline in Medical Use: Over time, the use of Nilevar in medical treatments declined. This was due to the development of more effective therapies with fewer side effects and the growing awareness of the potential adverse effects associated with long-term steroid use, including liver toxicity and negative impacts on cholesterol levels.

Sports and Doping

  • Adoption in Athletics: Like many anabolic steroids, Nilevar found a place in the world of sports and bodybuilding. Athletes and bodybuilders used it to enhance muscle mass, strength, and recovery times. However, its use in sports is illegal and against the rules of most sports organizations.
  • Doping Scandals: The use of Nilevar and other anabolic steroids has been involved in various doping scandals over the years. These incidents have led to stricter regulations and testing protocols in competitive sports to detect and deter steroid use.

Legal Status and Legacy

  • Regulation: The legal status of Nilevar varies by country but it has been classified as a controlled substance in many regions. This classification limits its use and distribution to certain medical conditions and under the supervision of a healthcare provider.
  • Legacy: Nilevar’s development marked a significant step in the field of steroid chemistry and therapeutics. It contributed to the understanding of how structural modifications of testosterone could produce compounds with different therapeutic and pharmacological profiles.

Nilevar’s history reflects the broader narrative of anabolic steroid development, usage, and regulation, encapsulating the challenges and controversies that have accompanied these substances since their inception.

Uses in body building

Taking a closer look at the molecular structure of Norethandrolone reveals that it belongs to the 19-nor steroid category. This classification suggests that it shares several traits with Nandrolone, earning it the nickname “Oral Deca.” While this comparison simplifies the drug’s complex nature, it serves as a useful starting point for understanding Norethandrolone. Like injectable Nandrolones, it exhibits progestin properties and is capable of aromatizing, meaning it can convert to estrogen and activate the progesterone receptor. Such activity makes Norethandrolone highly suppressive to gonadotrophin, potentially reducing the effectiveness of common ancillary drugs. Notably, Nolvadex may be less effective or even counterproductive due to its potential to increase progesterone receptor activity.

The 19-nor structure indicates a significant impact on natural testosterone production and the hypothalamic-pituitary-testicular axis (HPTA), which is crucial for regulating hormones within the endocrine system. Users might experience side effects like gynecomastia, acne, and water retention, contributing to an undesirable “smooth look.” To mitigate these effects, incorporating anti-progesteronic agents like Bromocriptine (2.5mg/day) and Letrozole (.5mg/day) could be beneficial for reducing water retention and estrogen levels, in addition to standard ancillaries that target estrogenic effects.

Despite these challenges, the 19-nor attribute of Norethandrolone also means it binds strongly to androgen receptors, promoting fat-burning. Initially, it may seem best suited for bulking phases, but with proper management of water retention, it could also be effective in cutting cycles. Those suffering from joint discomfort might find relief with Nilevar, similar to Deca. However, due to potential liver toxicity from its 17 alpha-alkylated structure, its use should be shorter than injectable counterparts. The advantage of its oral form is a quicker clearance from the body, estimated at about 5 weeks.

Innovatively, Nilevar could be particularly useful in the latter stages of intense bulking or powerlifting cycles, offering joint relief and anabolic benefits to support heavier lifting. While many oral steroids are available for various effects, Nilevar’s unique contribution to joint relief secures its value in comprehensive cycles, provided it can be sourced safely.

Nilevar dosage and administration

Nilevar, known chemically as Norethandrolone, is an oral anabolic steroid that was historically used for various medical conditions as well as for enhancing athletic performance and muscle growth. Its administration and dosage can vary depending on the intended use, whether for medical purposes or bodybuilding. However, it’s crucial to note that the use of anabolic steroids outside of prescribed medical treatment carries significant health risks and legal implications. The following information is provided for educational purposes only.

Administration

Nilevar is administered orally, making it more convenient than injectable steroids for many users. This oral administration means it has been chemically modified to survive metabolism by the liver, a modification that can increase hepatotoxicity (liver toxicity) risk. Thus, users should be cautious about the duration of cycles and co-administration with other hepatotoxic substances.

Dosage for Bodybuilding

  • Beginner Dosage: Individuals new to steroids might start with a lower dose to gauge their tolerance and minimize side effects. A typical starting dose might range from 20-30mg per day.
  • Intermediate to Advanced Dosage: More experienced users might consume between 30-60mg per day, though higher dosages increase the risk of side effects.
  • Cycle Length: Due to its potential hepatotoxicity, Nilevar cycles are usually relatively short, often recommended for 4-6 weeks to minimize liver strain.

Medical Dosage

Historically, when used for medical purposes, the dosage of Nilevar would have been prescribed by a healthcare provider based on the specific condition being treated and the patient’s response to therapy. It’s important to remember that its medical use has been largely discontinued in favor of safer and more effective treatments.

Considerations and Side Effects

  • Liver Health: Given its oral form and the risk of hepatotoxicity, users should monitor liver enzyme levels and consider liver support supplements or medications.
  • Estrogenic Effects: While not as prone to aromatization as some other steroids, Nilevar can still exhibit some estrogenic activity, leading to potential side effects like gynecomastia and water retention. Anti-estrogens might be used to mitigate these risks.
  • Androgenic Effects: Acne, hair loss, and virilization in women are possible due to Nilevar’s androgenic activity.
  • Cardiovascular Health: Anabolic steroids can affect blood lipid profiles, increasing the risk of cardiovascular disease. Monitoring cholesterol levels and maintaining a cardiovascular-friendly lifestyle is advisable.
  • Suppression of Natural Testosterone: Like many anabolic steroids, Nilevar can suppress the body’s natural testosterone production, necessitating a post-cycle therapy (PCT) to help restore hormonal balance

Points to consider when stacking Nilevar

When considering a steroid stack involving Nilevar (Norethandrolone), it’s important to remember that Nilevar is known for its progestogenic activity and potential for estrogenic side effects like water retention, gynecomastia, and suppression of natural testosterone production. Therefore, when stacking steroids with Nilevar, one might look for compounds that complement its effects, offer benefits that Nilevar lacks, or help mitigate its side effects. Always keep in mind that using steroids carries significant health risks and should be approached with caution and awareness of legal implications. Consultation with a healthcare professional is strongly advised. Here are some considerations for stacking with Nilevar:

1. Testosterone

  • Rationale: Testosterone is a foundational steroid in many stacks due to its potent anabolic effects. It can help ensure that the body continues to have an adequate supply of testosterone, given Nilevar’s suppressive effect on natural testosterone production.
  • Consideration: Estrogenic side effects might be exacerbated when stacking with testosterone, necessitating the use of aromatase inhibitors (AIs) like Anastrozole or Letrozole to manage estrogen levels.

2. Anastrozole or Letrozole (Aromatase Inhibitors)

  • Rationale: To counteract the estrogenic effects associated with both Nilevar and potentially added testosterone, incorporating an AI can help reduce the conversion of testosterone into estrogen.
  • Consideration: AIs should be used judiciously to avoid driving estrogen levels too low, which can have its own set of side effects.

3. Trenbolone

  • Rationale: Trenbolone is another 19-nor steroid known for its strong anabolic and androgenic effects without the conversion to estrogen. It could theoretically complement Nilevar by providing significant muscle-building effects without additional estrogenic side effects.
  • Consideration: Trenbolone is also highly suppressive and carries its own set of potential side effects, including those related to progesterone. Using two 19-nor steroids together increases the risk of side effects, so this combination should be approached with caution.

4. Winstrol (Stanozolol)

  • Rationale: Winstrol is a DHT-derived anabolic steroid that promotes fat loss and muscle definition without estrogenic side effects. It could help counteract the water retention associated with Nilevar.
  • Consideration: Winstrol can be harsh on the joints, which may be problematic if using Nilevar for joint relief. It’s also hepatotoxic, adding liver strain to the stack.

5. Primobolan (Methenolone)

  • Rationale: Primobolan is known for its mild anabolic effects and low androgenic activity. It doesn’t convert to estrogen and could provide a milder option for stacking with Nilevar, aiming for lean muscle gains.
  • Consideration: Primobolan is one of the milder steroids, which means it might not provide the significant bulking effects some users seek. It’s also relatively expensive.

Conclusion

Nilevar, chemically known as Norethandrolone, holds a unique place in the history of anabolic steroids, especially within the realm of bodybuilding. As one of the first oral anabolic steroids to be introduced to the market, its release by Searle in 1956 marked a significant advancement in performance-enhancing drug development. Designed with the intent of providing anabolic benefits with reduced androgenic side effects, Nilevar offers a fascinating study in the balance between maximizing muscle gains and minimizing adverse health impacts.

In bodybuilding, Nilevar’s anabolic to androgenic ratio of 100-200:22-55 suggests that it was intended to offer substantial muscle-building potential with a lower risk of androgenic side effects such as acne, hair loss, and virilization in females. Its efficacy at doses of 20-40mgs per day, coupled with an active life of 12-16 hours, made it a practical choice for athletes seeking daily strength improvements and muscle gains. The detection time of 5 weeks also offered a strategic advantage for competitors aiming to cycle off in time for drug-tested events.

However, the journey of Nilevar in the bodybuilding community has been nuanced. Its classification as a 17-alpha-alkylated steroid raises concerns about hepatotoxicity, necessitating careful cycle planning and liver health monitoring. The drug’s ability to aromatize, albeit less so than testosterone, requires users to manage estrogenic side effects such as gynecomastia and water retention. These side effects underscore the importance of responsible use, including considerations for post-cycle therapy (PCT) and potential integration of anti-estrogens or aromatase inhibitors.

Despite these challenges, Nilevar’s contribution to the development of bodybuilding physiques cannot be understated. It paved the way for the exploration of other anabolic steroids and performance-enhancing drugs, expanding the toolkit available to athletes for achieving their bodybuilding goals. The emphasis on Nilevar’s role in bodybuilding history is not just a reflection of its chemical properties or its efficacy but also a testament to the evolving understanding of steroid use in sports, the continuous quest for balance between benefit and risk, and the ethical considerations that accompany the use of performance-enhancing drugs.

In conclusion, Nilevar’s legacy in bodybuilding is a complex tapestry woven from its pioneering role in steroid development, the advancements it spurred in performance enhancement, and the ongoing dialogue it inspired about health, ethics, and the pursuit of excellence in sport. As the community moves forward, the lessons learned from Nilevar’s era remain crucial guiding posts in the responsible and informed use of anabolic steroids in bodybuilding.

Raw Data

  1. Chemical Identity
    • [17-alpha-ethyl-19-nor-4-androstene-3-one, 17b-ol]
    • Formula: C20 H30 O2
    • Molecular Weight: 302.4558
  2. Physical Properties
    • Melting Point: 130-136
  3. Pharmacokinetics
    • Active Life: 12-16 hours
    • Detection Time: 5 weeks
  4. Dosage and Effectiveness
    • Effective Dose: 20-40mgs/day
    • Anabolic/Androgenic Ratio (range): 100-200/22-55
  5. Manufacturing and Availability
    • Manufacturer: Searle
    • Release Date (in USA): 1956